The Role of Glutamate and Peripheral N-Methyl-D- Aspartate (NMDA) Receptors in Masticatory Muscle Pain Mechanisms

Citation for published version (APA): Cairns, B. E. (2016). The role of glutamate and peripheral N-Methyl-D-Aspartate (NMDA) receptors in masticatory muscle pain mechanisms. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. ? Users may download and print one copy of any publication from the public portal for the purpose of private study or research. ? You may not further distribute the material or use it for any profit-making activity or commercial gain ? You may freely distribute the URL identifying the publication in the public portal ? Take down policy If you believe that this document breaches copyright please contact us at [email protected] providing details, and we will remove access to the work immediately and investigate your claim. †This dissertation is based on the following peer-reviewed articles referred to by their Roman number in the text. i. in human pain and rat afferent discharge evoked by injection of glutamate into the masseter muscle. excitatory amino acid receptors decreases the duration of local anesthesia. BJ. Glutamate-evoked pain and mechanical allodynia in the human masseter muscle. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. KM. Systemic administration of monosodium glutamate elevates intramuscular glutamate levels and sensitizes rat masseter muscle afferent fibers. Cairns BE. Sex-related differences in glutamate evoked rat muscle nociceptor discharge result from estrogen-mediated modulation of peripheral NMDA receptors. neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis. P. Interstitial glutamate concentration is elevated in the masseter muscle of myofascial temporomandibular disorder patients.induced mechanical sensitization of the masseter muscle is mediated by increased that primary afferent fibers expressed receptors for a major excitatory central nervous system neurotransmitter like glutamate. Indeed, one well known pain researcher (who will remain nameless) commented to me at the time that even if receptors for glutamate were present on primary afferent fibers, it was likely an epi-phenomenon and had no importance for pain transduction in the periphery. Fortunately, others could be persuaded to at least consider the possibility. In particular, I am indebted to Professors Jimmy Hu and Barry Sessle, who allowed …